Scleroderma (systemic sclerosis) treatment involves a multidisciplinary approach and may vary based on individual symptoms and disease progression. There is no single "best" medicine for Scleroderma. Depending on the symptoms doctor may prescribe drugs, Blood pressure medications: These medicines help dilate blood vessels and may help treat Raynaud's phenomenon. Immunosuppressant drugs: Medicines such as those taken after organ transplant surgeries. This help reduces the progression of the thickening of the skin or the worsening of lung damage. Antacids: Pills that treat stomach acid and in turn reduce heartburn. Medications that help move food through the intestines, as these drugs may help reduce bloating, diarrhea, and constipation. Your doctor should make all treatment decisions based on an individual's unique condition.