A high protein S level is relatively rare and is usually not a cause for concern. Temporary increases in protein S levels can occur during acute inflammation or in response to certain illnesses. Consult your doctor if your test results are abnormal. They will interpret the results to determine the significance of high protein S levels and will help you with further investigation or treatment if necessary.

Protein S deficiency can be inherited or acquired. Symptoms or indications of protein S deficiency may include: 1. History of blood clots: Protein S deficiency increases the risk of abnormal blood clotting, leading to disorders like pulmonary embolism, deep vein thrombosis (DVT), or recurrent miscarriages in women. 2. Family history: Inherited protein S deficiency often runs in families, so a family history of blood clots or known protein S deficiency increases the suspicion of the condition. 3. Frequent or unusual blood clotting: Individuals with protein S deficiency may experience recurrent or unusual blood clotting events, especially at a young age or without apparent risk factors. 4. Pregnancy complications: Women with protein S deficiency may have a higher risk of complications related to the pregnancy, such as recurrent miscarriages, preeclampsia, or fetal growth restriction. If protein S deficiency is suspected based on clinical symptoms or family history, a healthcare professional may order specific laboratory tests to measure protein S levels. These tests may include total protein S antigen or functional assays to evaluate the activity of protein S.